Niacinamide is a popular and versatile skincare ingredient known for its numerous benefits, but there are certain combinations to avoid to maximize its effectiveness and prevent potential interactions. Here's a guide on what not to mix with niacinamide:

1. Alpha Hydroxy Acids (AHAs) and Beta Hydroxy Acids (BHAs):

Avoid using niacinamide in conjunction with strong AHAs (such as glycolic acid) or BHAs (such as salicylic acid) in high concentrations. Combining these ingredients can alter the pH of the skin and potentially reduce the efficacy of both ingredients. If you want to use both, consider using them at different times of day or on alternate days.

2. Retinoids:

Niacinamide can generally be used with retinoids (such as tretinoin or adapalene) without significant adverse effects. However, some sources suggest avoiding immediate simultaneous use to minimize the risk of potential irritation, especially for sensitive skin. Consider using niacinamide in the morning and retinoids at night, or consult with a dermatologist for personalized advice.

3. Peptides:

Niacinamide is generally compatible with peptides and can be used together in skincare routines. However, there are anecdotal reports suggesting that very high concentrations of niacinamide (10% or higher) may reduce the effectiveness of peptides. To be safe, use products containing both ingredients as directed and observe how your skin responds.

4. Copper Peptides:

Some experts recommend avoiding combining niacinamide with copper peptides due to potential interactions that may reduce the effectiveness of both ingredients. If you're using products containing copper peptides, consider using them at different times of day or consulting with a skincare professional for guidance.

5. High-PH Products:

Avoid using niacinamide with products that have a very high pH, such as alkaline cleansers or certain exfoliants. High-pH products can potentially reduce the effectiveness of niacinamide by altering its pH and affecting its stability on the skin.

Conclusion:

While niacinamide is generally well-tolerated and versatile, it's important to be mindful of potential interactions with other skincare ingredients to optimize its benefits and avoid potential irritation. When in doubt, start with lower concentrations, introduce one new product at a time, and listen to your skin's feedback. If you have specific concerns or questions, consult with a dermatologist or skincare professional for personalized recommendations.